Clonal Population of Mycobacterium tuberculosis Strains Reside within Multiple Lung Cavities

Clonal Population of Mycobacterium tuberculosis Strains Reside within Multiple Lung Cavities

BACKGROUND Unsuccessful treatment outcomes among patients with multi-/extensively-drug resistant tuberculosis (TB) have hampered efforts involved in eradicating this disease. In order to better understand the etiology of this disease, we aimed to determine whether single or multiple strains of Mycobacterium tuberculosis (MTB) are localized within lung cavities of patients suffering from chronic...

Particular Distribution of Enterobacter cloacae Strains Isolated from Urinary Tract Infection within Clonal Complexes

Background: Based on biochemical properties, Enterobacter cloacae represents a large complex of at least 13 variant species, subspecies, and genotypes that progressively identified as the most species causing hospital-acquired infections. The aim of this study was to determine the relevance between phylogenetically related strains within the E. cloacae complex and the frequency of urinary tract...

SNP/RD Typing of Mycobacterium tuberculosis Beijing Strains Reveals Local and Worldwide Disseminated Clonal Complexes

The Beijing strain is one of the most successful genotypes of Mycobacterium tuberculosis worldwide and appears to be highly homogenous according to existing genotyping methods. To type Beijing strains reliably we developed a robust typing scheme using single nucleotide polymorphisms (SNPs) and regions of difference (RDs) derived from whole-genome sequencing data of eight Beijing strains. SNP/RD...

Infectiousness of drug-resistant Mycobacterium tuberculosis strains

October 2007, Vol. 97, No. 10 SAMJ Drug-resistant tuberculosis (TB), and especially multidrugresistant (MDR) TB (i.e. resistance to isoniazid and rifampicin with or without resistance to other drugs) or extensively drug-resistant (XDR) TB (i.e. MDR resistance plus resistance to the fluoroquinolones and one of the second-line injectables – kanamycin, amikacin or capreomycin),1 has very important...

Discrimination of Mycobacterium tuberculosis strains by PCR.